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KMID : 0606920070150020083
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Biomolecules & Therapeutics
2007 Volume.15 No. 2 p.83 ~ p.88
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Neurotrophic Factors Mediate Memory Enhancing Property of Ethanolic Extract of Liriope platyphylla in Mice
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Mun Jung-Hyun
Lee Sang-Gon
Kim Dong-Hyun
Jung Ji-Wook
Lee Seung-Joo
Yoon Byung-Hoon
Shin Bum-Young
Kim Sun-Ho
Ryu Jong-Hoon
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Abstract
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The roots of Liriope platyphylla (Liliaceae) are widely used in traditional Chinese medicine. In the present study, we investigated the effects of ethanol (70%) extract of the roots of Liriope platyphylla (ELP70) on learning and memory using behavioral and immunohistochemical methods in mice. Control animals were treated with vehicle (10% Tween 80). With sub-chronic treatments of ELP70 (p.o.) for 14 days, the latency time was significantly increased compared with that of the vehicle-treated control group (50, 100 and 200 mg/kg; P<0.05). Moreover, immunopositive cells for brain derived neurotrophic factor (BDNF) were significantly increased in the hippocapmpal dentate gyrus and CA1 regions after ELP70 treatments for 14 days (50, 100 and 200 mg/kg; P < 0.05). In addition, those cells for nerve growth factor (NGF) were also increased in the hippocapmpal dentate gyrus region (50, 100 and 200 mg/kg; P<0.05). These results suggest that the sub-chronic administration of ELP70 improves learning and memory, and that their beneficial effects are mediated, in part, by the enhancement of BDNF or NGF expression
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KEYWORD
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Liriope platyphylla, Memory, Passive avoidance test, NGF, BDNF
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